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  • Ambroxol - ALZFORUM
    Ambroxol is a mucolytic compound and the main ingredient of over-the-counter cough medicines sold in many countries Syrup, tablet, and other forms are used at doses of 30 to 120 mg per day to reduce or thin mucous secretions and ease sore throat pain The most common side effects are gastrointestinal Ambroxol is unavailable in North America
  • Ambroxol Hydrochloride Improves Motor Functions and Extends . . . - ALZFORUM
    Bouscary A, Quessada C, Mosbach A, Callizot N, Spedding M, Loeffler JP, Henriques A Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis
  • Emrusolmin - ALZFORUM
    Background Anle138b is an oral, brain-penetrant, general inhibitor of protein aggregation It was identified in a high-throughput screen for small-molecule inhibitors of α-synuclein and prion protein oligomerization The compound is being developed for treatment of the rapidly progressing synucleinopathy multiple-system atrophy (MSA) and for Parkinson's disease (PD) It could potentially be
  • Early initiation of ambroxol treatment diminishes neurological . . .
    Early initiation of ambroxol treatment diminishes neurological manifestations of type 3 Gaucher disease: A long-term outcome of two siblings Eur J Paediatr Neurol 2021 May;32:66-72
  • Therapeutics Search | ALZFORUM
    NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-1088 ABBV-552 ABBV-916 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24 060 ACI-3024 ACI-7104 056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 AL003 AL044 AL101 ALIA-1758 Allopregnanolone ALN-5288 Alpha-Tocopherol ALX-001
  • Large Phase 2 Trial Starting Up in Genetic Parkinson’s Population
    Researchers in Canada recently evaluated the ability of the chaperone ambroxol to stimulate GBA activity in a small Phase 2 Parkinson’s study, and a similar trial of ambroxol is starting up in London
  • www. alzforum. org
    www alzforum org
  • Therapeutics | ALZFORUM
    AD Target Therapy Types The two tables below organize the therapeutics within this database by therapy type and proposed target type The number of therapeutics within each category is indicated according to the highest phase each therapeutic has achieved in U S clinical trials For example, if a given therapeutic is in both Phase 2 and Phase 3 trials, it is included in the Phase 3 total
  • α-synuclein KO Mouse (Nussbaum) - ALZFORUM
    Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice Ann Neurol 2016 Nov;80 (5):766-775 PubMed Krejciova Z, Carlson GA, Giles K, Prusiner SB Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein Acta Neuropathol Commun 2019 May 20;7 (1):81 PubMed
  • ALZFORUM | NETWORKING FOR A CURE
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